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This particular pattern may be explained by the underlying biology of brain development, with respect to different timing in the development of the cortex compared to the cerebellum during late gestation and also within the adult brain [26].
This is well demonstrated elsewhere embryologically in the failure of proper timing in the development of the heart valves, producing congenital heart lesions, and similarly in the time orderliness of the development of the eye.
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Although relative cranial ossification sequence is largely conserved across mammals [ 23, 24], there is a delay in raw timing between the development of bones in the oral region and those in the neurocranium of marsupials compared with placentals [ 25- 27].
Changes in the timing of the development of organs and structures is a process called heterochrony (Gould 1977), and the forms of expression have been described qualitatively and quantitatively by de Beer (1951), Gould (1977), Alberch et al. (1979), McKinney and McNamara (1991), Zeldrich (2001), and references therein.
P. vivax has marked differences in the timing for the development of different stages and the target cells, when compared with other Plasmodium species that infect humans.
Interestingly, the difference in the timing of the decline in L50 of R. argentea across Lake Victoria is consistent with the difference in the timing of the development of the R. argentea fishery (both occurred about a decade earlier in the Mwanza Gulf relative to the Napoleon Gulf).
The most significant differences in development in the two taxa reflect differences in the relative timing of the development of the central nervous system and somatic structures.
In addition, the timing for the development of new meningococcal vaccines was perceived as appropriate.
This is consistent with the timing of the development of blood vessels in mammalian muscle [ 32].
A better understanding of mechanisms and the timing of significant biologic events in the development of OA and PTOA will allow investigators to determine optimal timing for biologic interventions in the future [ 4].
The role of timing in play and the development of attention has not been a traditional focus in developmental neuroscience research.
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