The exact timing of the onset of sepsis in patients is unclear, as some present at different times in the course of the systemic response.
Records from all disciplines – including medical, nursing, therapy, social work and old age psychiatry – provided insight into events, which were often unobserved, and added clarity concerning the timing of events in the course of the person's admission.
Our study extends the previous observations by Rehberg et al (14, 15) and Maybauer et al (16) and further explores the best timing of administration in the course of sepsis.
The difference in the timing of the course of the epidemic in the friend and random groups could be exploited in at least two different ways.
This visual discrimination task was designed to measure rule learning and detect any changes in response timing over the course of testing.
In C. elegans, fat accumulation has been found to be associated with either shortened or extended life span [ 48, 78- 82], probably reflecting differences in fat localization, structure, or timing of fat abundance in the course of development.
A study by Ospina-Tasconet al. demonstrated the importance of the timing of fluid administration in the course of sepsis, and the authors found that early fluid resuscitation was effective in improving the microcirculation; however, giving fluids later in the course of sepsis was ineffective in improving microcirculatory hypoperfusion.
Similarly, timing along the course of ischemia-reperfusion may be crucial [ 3].
The large "error" at the start of the tone burst stimulus presumably reflects the rapid decrease in tau-m as depolarization activates K currents – affecting the timing of the response even in the course of one stimulus cycle.
