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miRNAs have been reported to be involved in many biological processes, including developmental timing, differentiation, proliferation, cell death, and metabolism [10], [11], [12].
MiRNAs regulate virtually every aspect of biology, including developmental timing, differentiation, proliferation, antiviral defence and metabolism [ 2].
microRNAs (miRNAs) have been reported to control diverse aspects of biology, including developmental timing, differentiation, proliferation, cell death, and metabolism [ 1- 3].
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In support of the hypothesis that core-promoter type influences the dynamics of expression, expression levels of several TATA-box binding protein associated factors (TAFs) and other core promoter-associated components changed during this developmental time course, and a testes-specific TAF (tTAF) played a critical role in timing cellular differentiation within the wing.
We have also identified a role for Creb1 in the timing of differentiation of the proximal lung epithelium.
These results suggest that heterogeneity indeed exist among various hiPSC lines, and timing of differentiation is also a matter.
Indeed, forkhead genes often collaborate with other transcription factors to control the timing of differentiation, exerting both positive and negative effects on these processes [2].
This suggests that pRb is required to temporally regulate these changes such that expression of specific cadherins is triggered with the right timing during differentiation.
FPN priming allows the maintenance of a larger pool of immature oligodendroglial progenitors, likely by a selective more then and inductive mechanism, without significantly modifying their timing of differentiation.
These observations suggest that murine and hNSCs might share responsiveness to a set of growth factors that control lineage specification, OPC survival and proliferation, envisaging species-specific differences regarding the timing of differentiation in response to these factors.
Differently, in our T. cruzi model we observed that increasing the size of parasite inoculum accelerated the parasitemia and the timing of differentiation and expansion of cytotoxic CD8+ T cells (Fig. 3).
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