Ultimately, detailed mechanistic studies for let-7 biogenesis and its regulation involved in the developmental timing, cell division and differentiation in animals should be elucidated.
miRNAs regulate various biological functions including developmental timing, cell proliferation, neuronal cell fate, apoptosis (reviewed in [12], [13]), neuronal gene expression [14], brain morphogenesis [15], muscle differentiation [16], and stem cell division [17].
[14] MicroRNA have been shown to impact a wide variety of physiological activities including developmental timing, cell proliferation, cell death, and hematopoiesis through a combination of direct effects on target gene expression and a cascade of secondary effects.
MicroRNAs can regulate the expression of their target genes at multiple levels, blocking mRNA translation and/or inducing mRNA degradation [16], and have been suggested to play roles in a broad range of biological processes, such as developmental timing, cell growth and differentiation, apoptosis and cell proliferation.
They regulate a wide variety of biological processes, namely developmental timing, cell differentiation, cell proliferation, immune response and infection.
It has been proposed that Band III is the major methylated protein, particularly for timing cell death [ 29].
It has been demonstrated that miRNA control major cellular processes, including metabolism, developmental timing, stem cell division, cell growth and differentiation and apoptosis [ 3- 5].
Here, we demonstrate a direct relationship between the intensity of ER stress in Purkinje cells and timing of cell death.
In recent years, important roles for miRNAs were identified in developmental timing, tumorigenesis, cell proliferation, and cell death [ 6, 7].
We analyzed the growth of the pericarp following pollination to establish the timing of cell division and cell elongation in the developing LA1589 pericarp.
In our representation, the timing of cell death is the time from when a cell divides until it essentially disappears and becomes "untrackable".
