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When methylated xanthines were administered to the laboratory animals in active phase (human "morning), as if they had a cup of black coffee, their body clocks' timing returned to that of an earlier time of day... when [they] were given toward the evening hours, once again there was a dramatic reaction, only this time the body clocks' timing altered to that of a much later hour.
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Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations.
However, it is far more likely that, as previously observed in T7 phage, genes with no direct role in cell lysis affect lysis timing by altering timing of lysis gene expression or by indirect effects on other stages of the life cycle rather than lysis mechanisms per se [ 17, 20, 49].
Developmental timing alters the functional impact of pathway activation on cortical neuronal precursor cells (Hirabayashi and Gotoh, 2005).
However, precise spike timing was altered significantly: cross-correlations of Gaussian current injections delivered alone vs. delivered with concurrent illumination resulted in zero-lag cross-correlations that were on average 37% smaller than cross-correlations of pairs of spike traces resulting from Gaussian current injections alone (p<0.005, see Methods for details of this analysis).
Therefore, replication timing was altered in rpd3 mutants, and so was the nucleosomal organization around origin regions.
ORCA could be functioning in a similar fashion as an organizer of heterochromatin, and therefore, in cells lacking ORCA replication timing is altered.
We confirmed that origin replication timing was altered in our rpd3Δ sample by examining origin activation of the early origin ARS305 and the late origin ARS603 during S phase as described in Additional file 5: Figure S4.
Common probing techniques used to access internal signal values (logic and timing) and alter the execution and timing behavior of an integrated circuit in a controlled manner are covered.
Our data revealed a correlation between origin structure and replication timing and we therefore wondered whether histone acetylation might modify replication timing by altering the chromatin architecture of replication origins.
For plants, the timing of seed germination is critical for offspring survival in stressful environments, as germination timing can alter the environmental conditions a seedling experiences.
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