Sentence examples for timing alterations from inspiring English sources

We next asked whether there are associated patterns of replication timing alterations in other cancer cell types.

We further find that domains of replication timing alterations in prostate cancer cells correlate with previously observed domains of long-range transcriptional and epigenetic remodelling for both LRES18 and LREA17 regions, whereby earlier domains become more active and later domains become more repressive.

The present study was aimed to gain some insight into the mechanism leading to the replication timing alterations of genes in blood lymphocytes of cancer patients.

The present study was aimed to gain some insight into the process leading to the replication timing alterations of genes in the blood lymphocytes of cancer patients.

Yet, the aberrant epigenetic profile in blood cells of the cancer patients was reverted to normal in the presence of AZA, a classical methylation blocking agent, linking the global cancer-related replication timing alterations to methylation capacity (discussed later).

These findings confirm our previous findings of cancer-related, non-locus specific replication timing alterations of loci (that normally replicate synchronously) in blood lymphocytes of patients with a solid tumor (see Introduction).

To determine the exact nature and timing of alterations in thyroid function throughout controlled ovarian hyperstimulation (COH).

However, the relationship between replication timing and epigenome alterations in cancer, and the combined impact on shaping the genomic landscape of tumour cells has remained largely unexplored.

Therefore, given the long-range domain level of epigenetic change observed in cancer, we were motivated to ask what is the relationship between replication timing and associated alterations to the epigenome and genome in cancer.

The timing of these alterations to US military doctrine and rules of engagement raises questions about the expanding role of the US military in a period when a new president has promised troop withdrawals from Iraq and the final phase of US operations in Afghanistan as well as military reform.

Conditional mutagenesis systems permitting external control over the timing of genetic alterations are attractive as they allow phenotypic analyses of mutations in the context of the mature, or even aged, prostate gland.