That thickness is important, Dr. Sepúlveda said, because it allows for more precise determination of the timescale of changes.
A fast protein turnover speeds up the kinetics, but with a consequent high metabolic cost, while in the case of long-living proteins the timescale of changes in concentration can be comparable to the cell cycle time [ 30, 57], which can be of several hours.
Importantly, these mechanisms operate in all pregnancies and are a reflection of the role of developmental plasticity in ensuring adaptability to a changing environment on a timescale of change between that of selection (many generations) and homeostasis (minutes days).
From a dynamic systems point of view, the iterations should be frequent enough to reproduce a trajectory of change on a particular timescale, which in this particular case is the timescale of change over months or years.
However, quantifying the likely impact of preventive interventions requires rather complex scenario modelling, including specification of realistically achievable population distributions of risk factors, and the timescale of change, as well as the latent periods between exposure and outcome, and the rate of change following modification in exposure level.
Furthermore, quantifying the likely impact of preventive interventions requires rather complex scenario modelling, including specification of realistically achievable population distributions of risk factors, and the timescale of change, as well as the latent periods between exposure and outcome, and the rate of change following modification in exposure level (e.g., Soerjomataram et al, 2010).
It may be remarked that it is difficult to reconcile the slow timescale of these changes with the much more rapid changes in refraction, occurring within minutes, with blood sugar level found by Gwinup and Villareal [ 16] after the injection of glucose in diabetic subjects.
Processes on a wide range of timescales are represented by the simulations: surface-water flow at 10 min, wind at 1 to 4 h, rain at 6 h to 1 day, and groundwater flow at 1 day, with a multiyear simulation period amenable to the timescale of ecologic changes.
Clearly, an important experimental consideration is to set up the in situ experiment such that the NMR spectra can be recorded sufficiently quickly that the time resolution of the measurement is compatible with the timescale of the changes that occur in the adsorption process.
The timescale of these changes is about 25 years.
The timescale of the changes in the combined assessment, management and follow-up scores in the individual practices are illustrated in Figure 5.
