Sentence examples for timescale of binding from inspiring English sources
Further, we show that the large fluctuations in binding rate observed at the level of single time-steps are integrated and smoothed at the larger timescale of binding events, which explains the continuous model goodness-of-fit.
Our study reveals that the extra discreteness and stochasticity that a full RW model introduces are integrated at the timescale of binding events, to the same value given by the continuous model.
The timescale of the binding and unbinding interactions of IGF1 with IGFBPs and IGF1R is expected to be much shorter than the timescale of cell proliferation.
It is important to notice that the dynamics just described can be altered if the miRNA acts mostly on mRNA degradation and depends on the timescale of miRNA-mRNA binding-unbinding.
However, the fluctuation at this timescale does not tell us much, because the expected number of binding events with this rate at this timescale is 0.027.
The variations in the binding rate at the timescale of a whole simulation run thus averaged-out and were statistically indistinguishable from the continuous constant rate.
It is not yet known how these observations relate to shorter evolutionary timescales (e.g., within a given order), but a quantitative understanding of the first steps in TF binding evolution in closely related mammals would help to answer important questions, including the following: are there particular types of binding sites more robust to evolutionary changes?
Choose the type of binding.
But the results also imply that dissociation of the complex occurs only on a timescale of several hours, which is suggestive of a tight binding interaction.
In Nicotina alata, artificial deletion of two disulphide bonds reveals that one of the bonds is essential for protein binding to trypsin while the other bond markedly decreases the timescale of motion [19].
