However, this model still does not reproduce the correlations across timescales observed in real data.
This observation does not rule out pausing at these sites but suggests that such a pause would be much shorter than the other timescales observed.
The distinct dynamics for the two modules reflect the diversity of inhibitory synaptic timescales observed experimentally, with Martinotti cells displaying slow synaptic inhibition (Ti neurons), and basket cells showing faster inhibition decay (Gi neurons) (Silberberg and Markram, 2007).
The relatively long timescale changes observed in the broadband and narrowband signals could be related to a variety of factors.
While the NMR models provide a picture of the average structure of apoLp-III, it is expected that helical regions will fluctuate on the nanosecond timescale, as observed for smaller helical peptides.
Due to bistability of the considered switch, this dominant eigenvalue corresponds to very slow dynamics, thus leading to the very long timescale as observed in the simulations.
However, the global fitting does give insight into the origin of the long timescale "hump" observed in the [D4]EA versus EAL transients.
Previous authors examining computational neuronal networks with continuous driving (i.e. no explicit separation of timescales) have observed power-law dynamics [16, 27 29].
From these experimental results, an operating diagram was constructed based on the measured process parameters, their respective timescales, and observed effects on fiber morphology.
