Exact(5)
The model is compared with practice for injections of a model mixture of compounds on a standard high-performance counter-current chromatography instrument giving good agreement for compound elution order and the times to maximum concentration for the eluted components.
Times to maximum concentration and the terminal elimination half-life estimates were shorter in pregnant than in nonpregnant patients (Table 2).
Secondly, the intervention and follow-up periods were long enough to enable a fair comparison between multiple doses of antipyretics with differing times to maximum effect.
Five published trials 11 12 13 14 15 mostly tested the effects of single doses at selected time points (which can arbitrarily advantage one drug because of the difference in times to maximum effect 16), were largely done in secondary care, and reached conflicting conclusions.
A non-compartmental model with extravascular input for plasma data was used to estimate maximum MPA and MPAG concentrations (Cmax), times to maximum concentration (Tmax), 12-hour trough concentrations (C12 h), and AUC0-12 h, which was estimated with the logarithmic trapezoidal rule, and their MPAG/MPA AUC0-12 h and C12 h ratios were calculated.
Similar(55)
That said, the timing of implementation by countries, and time to maximum coverage, are important drivers of impact.
As was expected, the latency and the time to maximum of the intensity response were shorter than the latency and time to maximum of the hedonic response.
Median time to maximum intensity was 10 minutes (range, 0 to 180 minutes).
Time to maximum plasma concentration occurred within the first day post-dose.
The time to maximum concentration for METH and AMP following IM administration was 0.3 h.
Time to maximum concentration (Cmax) of E. coli NAR was greater for SL at all depths.
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