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Syndromic surveillance data based on ED visits related to gastroenteritis might be robust and timely surrogate measures of norovirus activity, given its characteristic wintertime seasonality.
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More recently, Internet search trends for terms related to gastroenteritis symptoms have been examined as timely surrogates for norovirus activity (26, 27 ); in the United States, high correlation with outbreaks was demonstrated at national and regional levels (26 ).
Whilst ICU admission can be seen as a surrogate for time to treatment in the critically ill, the fundamental factors determining outcome are likely to include specific interventions and the timely instigation of organ support.
For those patients that choose hemodialysis, one surrogate of education and preparedness is the timely placement of permanent dialysis vascular access.
The need for timely estimates of norovirus activity has led to previous efforts to develop surrogate measures of disease from other types of syndromic data.
On the other hand, sometimes surrogate end points can be the only way to show improvements timely.
If early surrogate response indicator could be established to predict final treatment outcome, it would help to allow timely adjustment of drug regimens and achieve the goal of pCR.
How timely!
And timely.
Sounds timely.
Big thanks to our surrogate.
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