As a recent study conducted by Engelen et al. revealed elevated TIMELESS expression in tissues undergoing active proliferation, the implication is that increased TIMELESS expression may be a characteristic of all highly proliferative cells, rather than one exclusive to cancer tissues.
Even if TIMELESS expression is elevated as a result of, rather than a precursor to, heightened proliferation, TIMELESS expression may represent a natural response to abnormal proliferative rates and its potential physiological significance in cancer cannot be discounted.
I keep this shrine, still on a white window, Still with a timeless expression, With her back to the west, a dying flame.
One thing remains perennially clear: humans' first impulse is to create a password they're sure they'll remember, so stupid passwords are basically a timeless expression of the storage limitations of the human brain.
One thing remains perennially clear: humans' first impulse is to create a password they're sure they'll remember, so stupid passwords are basically a timeless expression of the storage limitations of the human brain.
Treatments succeed or fail, and patients live or die, but genuinely acknowledging the experience and value of another human being is the ultimate and timeless expression of humanity.
Because of the negative impact of Timeless expression on ES cell viability, we turned to the complementary approach of gene silencing.
The plot indicates that TIMELESS expression is frequently elevated in tumor relative to normal tissues across multiple cancer types.
31 out of 32 analyses exhibited increased TIMELESS expression in tumor relative to normal tissues while only one showed decreased expression (Additional file 1: Table S2).
A volcano plot was generated using -log10 transformed P-values and the fold change of TIMELESS expression in tumor versus normal tissues extracted from each analysis.
A recent study has also shown that higher levels of TIMELESS expression in colorectal cancer tissue is associated with TNM stages III-IV and microsatellite instability [ 14].
