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Other cardiovascular risk factors should be treated in older adults with consideration of the timeframe of benefit and the individual patient.
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The benefits of identification of prediabetes and asymptomatic type 2 diabetes in older adults depend on whether primary or secondary preventive interventions would likely be effective and on the anticipated timeframe of the benefit of interventions versus the patient's life expectancy.
However, although this timeframe of intervention was enough for benefits in CV outcomes to appear in the short term, it was probably not long enough for tight BP control to further influence the progression of organ damage and hence to confer a protecting legacy against long-term complications.
This requires a judgement of appropriateness in the context of benefits and burdens within the timeframe of estimated prognosis.
Formerly of Benefit (FOB).
It was also suggested that individuals with long-standing type 2 diabetes, existing cardiovascular disease (CVD), and other comorbidities were unable to achieve cardiovascular benefit from better glucose lowering within the timeframe of these studies (16).
Treatment of hypertension is indicated in virtually all older adults, and lipid and aspirin therapy may benefit those with life expectancy at least equal to the timeframe of primary or secondary prevention trials.
Because mortality dominates benefits analyses, additional detail is given on the pollutants and timeframe of exposure (i.e., acute or chronic) for mortality.
This introduces uncertainty, but allows costs and benefits arising in future time periods that were not observed within the timeframe of the trial, to be estimated.
There are clear benefits to managing trauma patients at these tertiary centres within the albeit debated timeframe of the 'golden hour'.
The short timeframe of this study may not have allowed students an opportunity to overcome initial difficulties and to experience the benefits of reflective learning firsthand.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com