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During the study timeframe, we observed 10 (9.5%), and 41 (33.6%) recurrences, in ECC and LACC patients, respectively; 3 (2.8%) ECC and 4 LACC (3.3%) women refused to complete all study evaluations.

A 12-week intervention period was chosen as this was considered to be a sufficient timeframe to observe changes in exercise capacity following exergaming at home [ 15].

When the timeframe to observe death is fixed or is prolonged to the post-discharge period, these "discharge" biases may be countered.

This is a considerably longer timeframe than those observed for MMTV- myc mice (~11 months), MMTV-Ha- ras mice (~5.6 months) or MMTV- neu (~3 months) mice [ 17, 18].

On the other hand, the absence of N conformational exchange linebroadening for the 80′s loop when Gly is in the cis-peptide configuration of the minor slow exchange state [ 22] suggests that positive ϕ torsion angles for Gly are not energetically accessible from that state in a comparable population or timeframe to that observed for the trans-peptide configuration.

We focused on this timeframe because subjects were observed during a period when seroadaptation had not been recognized or discussed in the scientific, public health, or popular literatures.

Considering the evolutionary timeframe of mammals, we observed no evidence of positive natural selection for the SLC2A4 coding sequence, although inferences about ω using the Yang [37] approach has sufficient power for a protein with more than 500 codons, such as GLUT4 [48], [48].

It is interesting to note that despite the inclusion of instability elements this reporter did not exhibit the very short timeframe (2-3 h) oscillations observed in mouse neural progenitors expressing a Hes1-driven luciferase reporter that included an ubiquitination sequence [ 9].

However, the positive association disappeared in 12 and 24 months observing timeframe (Table  3).

Similarly, the decreasing trend of association between H2RA and TB following the extension of observing timeframe was also found (Table  4).

Eligible patients will be randomly allocated to receive saxagliptin (5 mg for patients with normal or mildly impaired renal function or 2.5 mg for those with moderate renal impairment) or placebo once daily during the approximately 5-year study period, the projected timeframe necessary to observe 1,040 MACE.

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