Increasing CpG density forms low density CpG islands which are more likely to have variable methylation and hence to be tissue-specific or developmental time-dependent.
Thus, one outcome of this study is that the parallel use of primary cortical cells and PC12 cells can help to elucidate the varying roles of developmental time-dependent programming of cells versus the contributions made by the changes in CSF composition with age.
Taken together, these findings indicate that SPS induces time-dependent sensitization, which resembles the developmental course of PTSD and represents an animal model for PTSD.
In other words, although their model is able to offer an explanation for cell differentiation in vulval development, it cannot capture the full non-autonomous nature of the developmental process, since it does not reproduce developmental trajectories, chreodes, in an accurate and fully time-dependent manner.
LY294002 inhibits normal and extraneous developmental angiogenesis in the zebrafish eye, in dose- and time-dependent manners.
We found that cortical miR-29a showed a time-dependent increase exclusively in postnatal stages while miR-138 increased gradually during the entire developmental stages analyzed (E12.5 P60), which is consistent with the miRNAs array analysis (Fig. 1A).
Indeed, as development is a complex time-dependent process, a system genetics approach would be appropriate in order to test the hypothesis of stage-specific developmental time variation at the genomic level.
Time-dependent signalling cues and environmental conditions have long been known to shape many processes in the fields of evolutionary and developmental biology.
Imposing differing behavioral experience following developmental Pb ± PS results in additional divergence of PTHM profiles, again in a sex, brain region and time-dependent manner, further increasing complexity.
Time-dependent perturbation theory.
