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Among imatinib-resistant patients, 4 patients transformed to AP with a time to transformation ranging from 415 to 630 days after bosutinib initiation and 6 patients transformed to BP with a time to transformation ranging from 42 to 476 days after bosutinib initiation.
HL transformation in CLL/SLL is most commonly seen in elderly men and the median time to transformation is 4.6 years.
This remained significant when time to transformation was analysed using a Cox regression model (P=0.001).
Seven patients developed sequential DLBCL secondary to the previous diagnosis of NLPHL with a median time to transformation of 8 years.
When also considering time to transformation, CD9 (P=0.02), EGFR (P=0.04), and COX2 (P=0.008) were still able to significantly predict progression (Table 2).
Thirty-nine oft oneone hundred and forty-eight cases progressed from dysplasia to cancer (26%) with a median time to transformation for these cases of 26 months.
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PV patients ⩽45 years have a longer median time to MF transformation of 20 years compared with transforming in a median 8 years for patients who are ⩾65 years.
It is built using an extension of the multi-type Bellman-Harris branching process formulated by Hyrien et al [ 14] (see also [ 19- 21]) and which allows the distributions of the time to cell transformation (e.g., division or death) to depend on the transformation ultimately undergone by the cell.
We suggest the use of the single neutron event storing to make the time to energy transformation more efficient in the case of time of flight inelastic scattering, where the conversion from angle and time to momentum and energy is necessary.
Overall, the median time to myelofibrotic transformation is approximately 7 16 years from time of ET diagnosis.
Based on both retrospective and prospective studies, median time to MF transformation is 8.5 20 years from time of diagnosis.
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