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Ancillary outcomes included length of disease-free period after the first and additional courses of intralesional therapy, time to outcome, number and timing of recurrences and adverse effects.
The secondary objectives are to determine the effect of rosuvastatin on the rate of cardiac death and aortic valve replacement and to assess the time to outcome during a follow-up of 3 to 5 years.
We also calculated the time needed for patients to become disease-free (time to outcome).
This ensures the correct type II error/study power for the relative improvement in median time to outcome.
Kaplan Meier survival curves will be used to compare time to outcome events in the Index WACARP Cohort.
Kaplan-Meier survival curves were estimated in both groups, and we compared time to outcome using a stratified log-rank test.
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Kaplan-Meier plots of time to outcomes will be plotted for patterns of tests and individual tests above.
Approach 4 is a MSM for a time to event outcome [ 10].
Standard methods of survival analysis were used to investigate time to event outcomes.
Time to event outcomes (progression-free survival and overall survival) were analyzed using Kaplan-Meier curves.
Analysis of time to event outcomes will employ survival analysis techniques [ 26].
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