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Barriers to study completion include time delays associated with patient accrual, inevaluability (IE), time to dose limiting toxicities (DLT) and administrative and review time.
Only time to dose escalation was longer in patients who were treated with immunomodulators [ 14].
Time to dose stabilization during both study phases was analyzed by the log-rank test.
Two patients had dose reduction because of both toxicity and continuous dosing (time to dose reduction 1.4 and 4.2 months).
Twenty patients (35.7 %) had ≥1 dose reduction; for any reason; the median time to dose reduction was 9.1 weeks (range 2.7 43.1).
Of 374 patients, 71 and 303 had baseline LIC <7 and ≥7 mg Fe/g dw, respectively; mean deferasirox doses were 20.7 and 27.1 mg/kg/day (overall average time to dose increase, 24 weeks).
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The other kind of animal studies are these where animals were exposed for different periods of time to doses of mobile phone radiation that are permitted by the current safety standards and that do not cause heating of the animal.
In this way the spread is limited and it is cheaper than having to get the vet in several times to dose different batches of animals.
Increased nurse to patient ratio decreased time to first dose.
Median time to first dose reduction was 57.0 days (range, 16 443).
The median time to first dose reduction was 55 days (range, 6 483 days) in the overall population.
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