Assume that, over some evolutionary time-span, changes in the organism environment and biological function are taking place in such a way that increased fitness is brought about by a thioredoxin enzyme of high stability, an enhanced rate of catalysis through the 'specific' Michaelis Menten mechanism and depressed rate of catalysis through the 'chemical-like' SN2 type of mechanism.
Over this time span, additional changes in the ecosystems driven by climate factors have also been accompanied by multiple severe wildfire years.
Because data were collected over a period of eight years, changes in technology during this time span, such as changes in data collection protocol, might have influenced obtained measurements.
The 150 terabyte data set is the first that will allow researchers to watch the fracturing of ice shells within a three week time span, nearly tracking changes on the ice in real time.
One limitation of our study was the short time span for assessing changes over time.
The prognosis of older patients with this disease over the same time span has not changed much and remains dismal.
Consequently, survival records are split into so called "elementary records" internally, each covering only the time span from a change in any covariate to the next.
In the GSS's longer time span, we do see changes, albeit much less dramatic ones than the rise in "nones" from 1991 to 2012.
A decade was considered an appropriate time span to detect temporal changes, since the estimated generation time of the ringed seal is c. 11 years (estimated by Palo et al. [ 16] after Smith [ 32]).
It has been shown, however, that several contractile and metabolic transcripts remain up- or down-regulated at remarkably constant levels between day 7 and day 28 in overloaded and unloaded hearts [3] which suggests that the regulation of the transcriptome has attained a steady state during this time span after a sudden change in hemodynamic load.
For those time series of small time span but large sequence trend changes, time segment calculated by PAA_ERR would get very close to the original sequence, and resulted in poor final segment results.
