In recent times, single dose of liposomal form of amphotericin B such as Ambisome has been shown to be highly effective against both VL and PKDL [ 28– 30].
In 2001 the Department of Health, in partnership with the Africa Centre, launched a PMTCT programme and, in keeping with policy at the time, single-dose Nevirapine was offered to HIV-infected women during labour, and their infants post-partum.
Based on the limited number of bleeding-related AEs and no evident effect on template bleeding time, a single dose of apixaban appeared to prolong clotting time in healthy subjects without excessively impairing haemostatic function.
A subgroup of 8/41 women initially included at delivery were recruited for a second single loading dose (2 g paracetamol) PK study 10 15 weeks after delivery and 7/8 women were re-evaluated a third time (single loading dose, 2 g) about one year after delivery [ 11].
Prolonged therapeutic action over an extended period of time on single dose is vital in designing an ideal drug delivery system.
For older children receiving the seasonal influenza vaccine for the first time, a single dose of the vaccine is appropriate.
To characterize the duration of efficacy in relation to compound exposure at different doses for ELN475516, we conducted a time course study in mice treated with 30, 100, and 300 mg/kg, and terminated at varying time points following single dose.
Mean Cmax and AUC24 values in the 1000 (+2 h) mg cohort were higher than those in the 1000 (−1 h) mg cohort by 3.1 4.2 times after a single dose and by 3.4 4.6 times after multiple doses (Fig. 2).
The better performance of the polymersomes as a cell tracker agent is also shown by the enhanced fluorescence intensity over time after a single dose (figure 3c d).
Obviously, we cannot predict the accumulation of drug over time from a single dose study analyzed with a model-independent analysis.
It is often restricted to the examination of a single exposure time and a single dose with few replicates, which may increase the false negative rates of the assay [ 4].
