Open image in new window Fig. 5 Time series change in water variables at the site measured every 15 min.
Figure 1: Time-series changes in mononucleotide composition for EBOV.
Figure 2: Time-series changes in dinucleotide compositions for EBOV.
Figure 4: Time-series changes in mono- and dinucleotide composition for MERS viruses.
Figure 6: Time-series changes in dinucleotide compositions for influenza viruses.
Hence, we analyzed time-series changes in pentanucleotide (5-mer) occurrences.
Collectively, we focused on thirteen subtypes (three human and nine avian A subtypes and a human B type), and first analyzed time-series changes in mononucleotide compositions.
Three influenza A subtypes may not be sufficient to judge the reoccurrence of the change, and therefore, our group has started to analyze the time-series changes in experimentally validated siRNA sequences, by focusing on both human and avian strains.
In the case of U%, human H1N1 (blue) and H3N2 (brown) have already reached the B's level, and only pH1N1 (green) shows an increasing trend toward B. Figure 5: Time-series changes in mononucleotide composition for influenza viruses.
In the recent West Africa Ebola outbreak, directional time-series changes in a wide range of oligonucleotides were observed in common for three geographic areas, and the directional changes were observed also for the recent MERS coronavirus epidemics starting in the Middle East.
