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Although discrepancy exists at t = 0, the predicted plasma concentration accurately demonstrates the time scale of clearance of nanoparticles from the blood into other organs.
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Changes in the model parameter values of N, ρ and GP within the admissible range (i.e. leading to the eventual clearance of pathogens by the host or low persistent pathogen load) alters the time scales of the response curves without affecting the overall shape characteristics of the pathogen load and immune response curves.
This physiology-based scaling of clearance was shown to accurately predict clearance in children from birth to adolescence (22, 23) and was found superior to that of allometric scaling.
B-cells in circulation are eliminated very rapidly, while the observed time-dependence of clearance has a longer characteristic time scale.
Because of the fast blood and renal clearance of the monomeric bisphosphonates, the time scale for target accumulation is shortened compared to the dimeric compounds.
In conclusion, the stochastic immune response model emphasizes the importance of elaborate IgG pooling in order to achieve a highly homogeneous IgG shape space distribution for the reliable clearance of infections on a reasonable time scale.
In light of it, we are expecting further research should provide standard time scales to better evaluate the clearance rate and recurrence rate of interferon therapy for genital warts.
However, currently, no standard time scales are available to measure clearance rate and recurrence rate in the treatment of genital warts.
Time scale.
Estimate for minimum clearance period required to exclude obvious readmissions was obtained using the method based on smoothed hazard function on backward time scale [ 27].
Figure 6 is a parallel coordinate plot for the scaled estimates of clearance from each model fit.
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