Exact(2)
Larger studies are required to establish the optimal time point for response evaluation.
It may be argued that MRI after 4 cycles is not an optimal time point for response evaluation during treatment.
Similar(58)
A potential reason is possible due to the different definition, especially different time point for patient's responses (for example, for prednisone response, D8 is used for the patient's response to prednisone therapy, but for risk group D33 is used).
For the more detail analysis, we examined the response of each metabolic pathway in each time point for these common heat response genes (see the additional file 1).
Blood tests will be collected during these time points for hematologic response assessment.
No significant findings were observed at any of the time points for EULAR response criteria, ACR20, ACR50 or ACR70.
Figure 2 shows the changes in DAS28 with time in parts A, B and C. No significant findings were observed at any of the time points for EULAR response criteria, DAS28 remission, ACR20, ACR50 or ACR70.
The selection of a different time point for the definition of non-response may have resulted in different outcomes.
As only LYS1 OE lines with a massively increased LYS1 protein level (lines 1 and 2) show an increased susceptibility to bacterial infection we believe it to be quite challenging to find the right time point for detecting differences in immune responses in LYS1 OE lines compared to wild type or LYS1 KD lines as the enhanced LYS1 enzyme activity is present at the beginning of all experiments.
We further evaluated ocular inflammation by histology at both 10 weeks and 16 weeks after zymosan injection, which had appeared by intravital videomicroscopy to be "peak" time points for intravascular responses.
This general function allows the user to specify time points for evoked responses, time windows for anticipatory, spontaneous, and baseline fluctuations; thus catering for experimental paradigms that extend the relatively simple design used here, and permitting analysis of multiple (and overlapping) anticipatory SCRs.
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