In both experiments, GA reproducibly induced a modest but statistically significant increase of the survival time of treated mice as compared to the solvent-treated mice (∼6%) when the drug was administered once or twice a week at 20 mg/kg.
Where Tt is the reaction time of treated group and Tc is the reaction time of control group.
It also increased the mean survival time of treated infected mice by between 28 and 35% relative to the infected untreated mice (P < 0.05 vs. control by Student's t-test).
Treatment with these inhibitors increased the survival time of treated cells from 6 12 h (untreated) to 16 24 h (treated with JNK or ERK1/2 inhibitors).
For experiments where treatment started 2 h post-infection the median survival time of treated mice is not computable because mortality is far less than 50% (based on pilot experiments).
T, mean survival time of treated diabetic group; C, mean survival time of untreated diabetic group.
The results are expressed as the ratio of the lysis time of treated cells to control cells.
Furthermore, in CRPC mouse model, rAAV2-hPEDF significantly suppressed tumor growth and metastasis, and prolonged survival time of treated mice.
Moreover, rAAV2-hPEDF significantly suppressed tumor growth and metastasis and prolonged survival time of treated mice in CRPC model.
