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Proper determination of the extent of disease on imaging studies at the time of staging is one of the most important steps in optimal patient management.
LKB1-deficient tumors were not more advanced at the time of staging, e.g., 28% of LKB1-wild type tumors were initially Stage I (confined to the uterus), vs. 43% for LKB1-deficient tumors, nor of higher grade (i.e. more poorly-differentiated).
At the time of staging, all patients had an Eastern Cooperative Oncology Group (ECOG) performance status of ≤2.
CA 19-9 kinetics were significantly correlated with TTP and OS only at time of staging (day 56).
At the time of staging (day 56), absolute levels of each analysed marker again showed a significant correlation with objective response.
Similarly, haematogenous spread, also previously considered uncommon, is prevalent at post-mortem (50 67%) and is being increasingly recognized as a mode of dissemination at the time of staging and follow-up[ 5].
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However, as the monomer content increases the monomer conversion and polymerization rate at stage I will rapidly decrease while the ending time of stage I rapidly increase.
Moreover, for St and MMA, the model predicts that as the ultrasonic intensity increases the monomer conversion and polymerization rate at stage I will rapidly increase while the ending time of stage I rapidly decrease.
Although systematic medical checks and the development of surgical treatments have contributed to the early detection and improved prognosis of GC, the median survival time of stage IV gastric cancer remains only 10 12 months [2].
The median survival time of stage IV patients with a high number of LC3A‐positive SLS was 3.55 months versus 13.6 months for those with a low number.
A total of 855 patients (56.4% male) with primary cutaneous melanoma were included in the survival analysis at the time of stage IV diagnosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com