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In one patient, the BAFF level did not increase until time of repopulation.
Also in patients with SLE the presence of memory cells as well as plasmablasts at the time of repopulation after rituximab therapy was associated with early relapse [ 62].
Upon B-cell depletion, BAFF levels increased relative to baseline (baseline: 1233.5 ± 683.3 pg/ml vs six months: 3257.8 ± 1571.8 pg/ml), while in one patient the BAFF levels did not increase until the time of repopulation.
n: total number of fractions d: size of fractions in Gy T: overall time of treatment (days, with first day as D0) Tk: onset (kick-off) time of repopulation in the tissue of interest: 21 days Tp: potential doubling time of cancer repopulating cells: 3 days α: radiosensitivity coefficient of non-recoverable damage: 0.35 The authors have no financial disclosures or conflicts of interest to report.
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The time point of repopulation tended to be earlier in moderate or non-responders than in good responders; however, this difference was statistically not significant.
Leandro and colleagues observed that RA patients experiencing disease relapse at the time of B-cell repopulation had a higher frequency of blood memory B cells as compared with patients without relapse [ 55].
These two α/β ratios, as pointed out by Fowler [ 18], differ in the assumption of the time of onset of the repopulation, which is late for the α/β =1.5Gy and early (of 0 or 28 days after starting the treatment) for the α/β =3.1Gy.
Infusion of F1 lymphocytes at the time of BMT impaired spleen repopulation, likely through competitive homoeostatic expansion with BM-derived lymphocytes in peripheral lymphoid organs (Teshima et al, 2001; Zöller, 2003).
Tumor repopulation is a major cause for tumor relapse, and the rate of repopulation might increase over time (Withers et al., 1988).
At this time repopulation of the peritoneal cavity is underway and immature and mature mast cells can be identified by their metachromasia [18].
For global migration, the distance of migration was obtained by measuring the area of repopulation of the gap between the time the scratch was generated (T0) and 6 and 12 h thereafter, using the ImageJ software.
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