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A strain, in which three origins were inactivated, confirmed that the distribution of termination events is primarily dictated by the stochastic activation time of origins.
These results suggest that Tel1 acts to set the firing time of origins by affecting the loading of Cdc45 in the G1 phase.
Centromeres advance origin activation time over a distance of 20 kb (Pohl et al. 2012; Natsume et al. 2013), whereas telomeres delay the activation time of origins over about 30 kb (Ferguson et al. 1991).
Thus, similarly to short telomeres, DSBs flanked by short TG-tracts led to a change in the activation time of origins of DNA replication from late to early S phase.
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The time of origin of orchids is in dispute, although Dressler suggests that they originated 80 to 40 million years ago (Mya; late Cretaceous to late Eocene) [ 6].
We used the established origination times of all human genes to trace the time of origin of intronized retrogenes [ 34] and examined the presence and absence of the corresponding orthologs in the vertebrates phylogeny (Additional file 6).
Given such a network of relative ages, a chronology of events has been gradually established in which the relative time of origin of various geologic features is known.
Ionium-thorium dating, method of establishing the time of origin of marine sediments according to the amount of ionium and thorium they contain.
Potassium-argon dating, method of determining the time of origin of rocks by measuring the ratio of radioactive argon to radioactive potassium in the rock.
This yielded a tracer with a well-defined time of origin that will be useful long into the future for following the course of such water in soils and aquifers (water-bearing layers of rock).
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