Fitting a Cox proportional hazards model with frailties confirmed a significantly earlier time of appearance (hazard ratio (HR): 2.6; 95% CI: 2.3 3.0), dominance (4.8 (3.4 6.8)), and completeness (3.6 (2.3 5.5)) of reverse mutations to the wild type Gag than escape mutations from the wild type.
However, for NovoTTF-100A responders, the peak hazard rate was lower than that for nonresponders and the time of peak hazard rate was delayed compared to nonresponders.
In contrast, the BPC cohort's hazard rate for responders peaked higher compared to nonresponders, while the time of peak hazard rate is also delayed in responders compared to nonresponders.
In multivariate analysis serum albumin ≥34 g/L at the time of procedure (hazard ratio 0.573; 95% confidence interval 0.424 0.773, P<0.001) and chemotherapy post-stent (hazard ratio 0.636; 95% confidence interval 0.455 0.889, P=0.008) were two independent prognostic factors predicting a better survival post-stenting.
Similarly, when calculating the time of settlement hazard onset, if the time cannot be detected for some grid cells due to a shallow soil layer depth of the climate model, these grid cells were removed.
The proportional hazard assumption was studied by Schoenfeld partial residuals and their correlation with the rank order of failure times and by introducing time dependent interaction terms for the covariates in the model to detect a possible trend over time of the hazard ratio [ 16, 17].
Specific risk factors for death during early ART included altered mental status at time of randomization (hazard ratio 3.0; 95% CI: 1.0 8.8) and failure to mount a cellular response in the CSF (CSF white cell count <5 cells/mm) (hazard ratio 3.3; 95% CI: 1.3 8.4).
Second, time-dependency of hazard ratios was accounted for by testing correlation of scaled Schoenfeld residuals with time [ 8].
In order to consider the hypothesis that any differences in eye movement characteristics between patients and controls were similar at the time of the hazards compared to sequences of the HPT where no hazards occurred, the films were divided into 'safe' and 'unsafe' segments.
Note that the survival functions cross at a time larger than the crossing time of the hazards, and may not cross at a finite time.
