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In addition, it supports the view that cytokines are not detrimental or beneficial by themselves, i.e., their level and time of expression among other factors can determine its final effect on CNS damage or protection.
We observed that these two plasmids produced a markedly different profile in the level and time of expression of the encoded-antigen, and this may have a direct effect upon the intensity and suitability of the in vivo immune response.
However, the diurnal pattern of OsYSL15 in Fe-deficient roots differed from the diurnal pattern of OsNAS1, OsNAS2, OsNAAT1, OsDMAS1 and OsTOM1 by having a peak time of expression at 18 00 20 00 instead of 11 00 13:00 (Fig. 2).
These include lowering of culture temperature (Hoffmann and Rinas, 2001), using early induction time of expression (Lim et al. 2000), nutrient and oxygen restriction (Ryan et al. 1989), increasing post-induction time, and regulating the inducer concentration (Manderson et al. 2006).
Thus, substrate specificity and time of expression might regulate the function of LplA1 and LplA2 in P. falciparum.
Thus depending on the regions and/or developmental time of expression, the sst2A receptor is likely to assume different roles during neuronal maturation.
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Three UVH6-related transcription factors show different peak times of expression in early conjugation, as do 3 PHD finger- and 3 CPP-related factors.
For instance, males 3B and 10B, with 2 copies of the SRY gene, showed 1.5 2 times the level of expression, whereas 9F, 10F, 31F, 32F, 33F and 33B, also with two copies, showed higher levels (around 4 9 times) of expression.
Using this spline model, we identified peak times of expression for cell cycle regulated genes.
In particular, Rev-erbα and DBP showed the clearest shifts in the peak times of expression.
For each gene, we defined peak times of expression as greater than the mean expression across all splined time points plus 1.25 standard deviations.
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