The baseline characteristics of study cohort including age, sex, tumor origin, prior treatment, and the site of metastasis at the time of dose escalation, the dose, and the reason for dose escalation were documented.
For patients with an hCG level under 300 IU l−1 single-agent dactinomycin was the standard treatment, whereas for women with an hCG level in excess of 300 IU l−1 at the time of treatment escalation EMA CO was the treatment choice.
The de-escalation group had slightly lower APACHE II score and a lower modified CPIS trend at the time of de-escalation compared to the non-de-escalation group, although both were not statistically significant.
De-escalation was not performed in patients with a category 3 APACHE II score and CPIS at the time of de-escalation.
"A lot of times the threat of escalation to that person does the trick.
[By the way, Sargant Shriver was in Pakistan when he received word that he was appointed director of the War on Poverty, just at the time of the Vietnam escalation, so in a sense we are full circle here.].
11 34 35 So, the balance between risk and benefit should be considered at the time of infliximab dose escalation, even in TNF-high patients.
July 13 Israeli planes strike Beirut for the first time, an escalation of the crisis that prompts fears of war with Syria.
Over shorter time periods, escalation of storm intensities will increase the probability that groundwater tables will rise above the bottoms of pits at some point during the year; thus, it is likely that contaminant transport from pit latrines to groundwater will increase.
In these patients there was a statistically significant median decrease in serum ferritin of 440 μg/l (P< 0·0001; Table III) from pre-dose-escalation to the time-of-analysis.
