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Because of a lack of published evidence at the time of effectiveness, cost-effectiveness and impact on inequalities, the panel did not vote in any majority fashion to invest further in any of the 25 interventions under review.
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One reason for this is the limitations for generalisation, particularly with respect to the impact of time on effectiveness.
Cook et al. [ 17] and Priestly et al. [ 22] also consider the impact of time on effectiveness.
Split-dose irradiation only slightly reduced the magnitude of suppression, provided both doses were given within the time window of effectiveness of single doses.
"[S]ystematic study over time of the effectiveness of the techniques would have been encumbered by a number of factors," the agency CIA told the Senate intelligence committee in June 2013.
Patients could discontinue the assigned treatment at any time for lack of effectiveness, side-effects, or by own choice.
They already manage their time for effectiveness instead of efficiency.
To establish, for a determined period of time, the effectiveness of a program of ultrasound screening in detecting fetal malformations in prenatal time.
But Dr. Woodley suggested that policy makers spend less time seeking proof of effectiveness and instead treat seeding as another resource.
However, it is important to underline that choosing which of these methods to use is often driven by a combination of a number of factors including: sensitivity, specificity, fitness-for-purpose, technical ease, and time and cost of effectiveness.
Although a traditional parallel trial design can be used to examine general secular trends it cannot explore the particular relationship between time of intervention and effectiveness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com