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Rumen and duodenal contents, and blood serum were collected at 0, 1, 3, 6, 9, 12, and 24 h relative to the time of dosing.
Brandes JL, Kudrow D, Cady R, Tiseo PJ, Sun W, Sikes CR (2005) Eletriptan in the early treatment of acute migraine: Influence of pain intensity and time of dosing.
Based on comparison of areas under the plasma concentration versus time curves from the time of dosing to the last time point at which eprinomectin B1a was quantified, and Cmax, dose proportionality was established.
Mice were weighed weekly at the time of dosing.
Post-dose measurements were calculated from the time of dosing.
This can lead to odd profiles around the time of dosing if the time points evaluated do not contain the exact time of dosing.
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The time of dose calibration and start of each scan were recorded for decay correction.
However, there was strong evidence of interaction between parasitaemia at time of dose and the protective efficacy of IPT over time (LRT p<0.001).
The primary analysis was performed unadjusted for covariates; the effect of adjusting for age at time of dose, sex and place of residence (rural or urban) was then explored.
If the measurements are repeated over the entire time of dose delivery, the cumulative dose can be determined.
Another limitation was that the exact time of dose administration relative to the time of drug concentration measurement was not known.
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