Sentence examples for time of acquired from inspiring English sources
No prior studies have demonstrated the enrichment of ES cell signatures in clinical samples collected at the time of acquired resistance to cytotoxic chemotherapy.
Here we demonstrate that the posttreatment samples collected at the time of acquired resistance, although difficult to obtain clinically, contain unique genomic information that can be used to predict the initial response to cytotoxic chemotherapy.
Our biologic data is supported by gene expression data showing that proangiogenic genes are upregulated at time of acquired resistance and largely revert following reimplantion of the resistant tumor into a naïve host.
Thus, the sampling and analysis of tumors at the time of acquired resistance remain a largely unexplored frontier.
A point mutation in the tyrosine kinase domain (T790M) is found in approximately half of patients at the time of acquired resistance to EGFR TKI therapy (Gazdar, 2009).
Short-term cultures of tumor cells derived from patients at the time of acquired resistance (both tumors EGFR genotype exon 19 deletion + T790M) were treated with the indicated agents for 24 hr, followed by isolation of total RNA and qPCR for SOX2 transcript (left panels) or quantitative immunofluorescence analysis after staining with antibodies to SOX2 (middle panels).
The parties who have made the commitment generally seek to hedge against the risk of price rise in the raw material between the time of making the forward contract and the time of acquiring the raw material stocks for fulfilling the contract.
The main limitations of NMR have been the cost and time of acquiring data.
The average waiting time along with the time of acquiring and releasing the lock is usually minuscule.
The performance characteristics were determined both for the ENTLN processor that had been in service at the time of acquiring triggered-lightning data (June 2009 to August 2012) and for the new ENTLN processor, introduced in November 2012.
If the patient was given adequate antibiotics before or at the time of acquiring the blood culture, the time to first adequate therapy was recorded as zero hours.
