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I can say from personal experience that nobody could have understood the situation in all its complexity at the time it unfolded.
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Here is how it unfolded.
Scientists are studying how it unfolded.
That is up to God". This is the story of how it unfolded.
Here's how it unfolded.
The key challenge is to uncover how it unfolded.
And that is just how it unfolded.
So that's kind of how it unfolded.
This time, though, when unfolded, it should make a v-shape.
What matters most is not a protein's stability or difficulty of folding, but its dwell time in an unfolded state.
The main guardian chaperone is DnaK because its client proteins spend more time unfolded than clients of GroEL, providing a mechanism for why the cell's capacity to handle stress is more sensitive to DnaK levels.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com