Exact(2)
At this time, intensification of insulin therapy is recommended 2, 4 and different approaches can be used 2, 5– 11.
It is observed in NHL-B2 that both, addition of etoposide and time intensification results in a better outcome, but that these factors are not additive.
Similar(58)
Dose and time intensifications of chemotherapy improved the outcome of lymphoma therapy.
Compared to CHOP-14, we predict only limited improvement of therapy by further time intensifications.
Finally, we used the hybrid model to simulate four different chemotherapy regimens comprising both, dose and time intensifications of therapy and growth-factor applications as well.
The schedules differ in application of etoposide (dose-intensification) and duration of therapy cycle (time-intensification).
For quantitative simulations we have considered four established chemotherapy regimen that serve as benchmarks, because they comprise dose- and time-intensification of therapy.
2004a), it has been shown that either dose- or time-intensification of the standard multi-drug chemotherapy containing cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) improves the outcome.
There is only limited potential to improve therapy by further time-intensifications and increasing number of cycles.
We also analyzed the effect a shorter (three years) treatment strategy assessment period would have on the calculation of the optimal systolic blood pressure target (as a large fraction of patients did not have any medication intensifications during the first three years, time to intensification and time to follow-up after intensification could not be defined).
We chose a 10 year treatment strategy assessment period because we found that shorter treatment strategy assessment periods are vulnerable to misclassification of time to intensification, as the assessment period may end before intensification occurs.
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