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In A. dolosus, the time frame of differentiation in the Azores is estimated at 1.71 Ma (node A, 0.34 4.6, 95 % HPD).
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As reported earlier [ 24], each region in our analysis identifies a moderate population bottle neck just before the manifold rapid growth, which probably suggests a time frame of Native American founder's divergence and differentiation from their Asian ancestors sometime around LGM and then rapid expansion into America.
In summary, neuronal progenitors are competent to generate neurons upon exposure to Tgfβ over the entire culture period, where upon a minimal time frame of 2 3 days is necessary to detect changes in the expression of differentiation markers.
Furthermore, in the presence of BMP4, downregulation of Oct4 is delayed, and markers that characterise EMT and overt mesoderm differentiation are not upregulated within the 5-day time frame of this experiment.
The appearance of lipid droplet-like inclusions that is a characteristic sign of MSC differentiation into adipocytes, was clearly visible after 9 hours exposure rather than in the typical time frame of several days.
The time frame of the French exhibition is important.
The time frame of the future gets narrower and narrower.
The time frame of these interventions spans almost a decade.
The time frame of this study will be 18 months.
The time frame of occurrence was 1958 through 2006.
A second limitation relates to the time frame of intervention.
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