In addition to the short time frame and limited observations of habitat use by frugivorous birds, this study has several other important limitations.
"Immediately this first issue," he says, is "why are you creating more?" He is, of course, pleased with some of the responses, which have included what must be the ultimate praise for an industrial designer: "How has no one thought of this yet?" He concedes that given the one-month time frame and other limitations, they could not fully address some of the problems that various critiques raised.
By offering relevant information on the sample size, research design, time frame and study limitations, Table 1 provides insight into the scientific and methodological quality of the included studies.
Missing information from those participants who could not provide answers to all questions within the study time frame was also a limitation.
More recently, calls have been made for 'rapid reviews' to provide decision-makers with the evidence they need in a shorter time frame, but the possible limitations of such 'rapid reviews', compared to full systematic reviews, require further research [ 2].
For example, our use of a "snapshot" time frame study is a likely limitation that does not allow us to take into account differences in mRNA versus protein half-lives.
A limitation of this model, as the authors acknowledge, is that it uses a limited time frame (10 years) rather than a lifetime perspective.
Applications of these scenarios should consider their scope and limitations: Long time frame – they are relevant in the scope of long time frame Contrasting – they are, to a significant extent, mutually exclusive Defining a range of plausibility – the scenarios are intended to present relatively radical futures which define the boundaries of plausible futures.
Such studies have mainly been performed in the acute time frame due to the inherent limitations of the most sensitive assays available and have generally involved exposures for 1 to 9 days, depending on the assays used.
Although the 1-month duration of this study represents one of its limitations, this time frame of assessing changes in FMD is regarded as clinically relevant, according to the recent EFSA consensus statement on the scientific requirements for studies aiming at supporting FMD-based health claims.
Despite the limitations posed by time frame restrictions in this study, previous studies have detected increases in condom use over similar intervals, among both high-risk and non-high-risk individuals.
