Only for the 5- and 10-year survival trends, there is some overlap of the time frame encompassed by both approaches.
As is evident from Figure 5, none of these compensatory mechanisms appears to be operative, at least within the time frame encompassed by these experiments.
This specific time-frame, encompasses a major risk of psychiatric morbidity [ 1].
Prenatal exposure to asymptomatic doses of domoic acid (DA) causes learning and memory deficits later in life; therefore, we sought to measure distribution of DA in maternal plasma and brain, prenatal brain, and amniotic fluid 1 hr after exposure, a time frame that normally encompasses acute seizure behavior.
These findings demonstrate that the time frame chosen for our study encompassed blastema formation rather than blastema outgrowth.
Researchers have clearly demonstrated that risk factors for IPV associated with pregnancy encompass the time frame of one year before conception until one year after childbirth [ 11– 15].
As a rough estimate, rat brain development at PND7 has been determined to approximate human brain development at birth (Clancy et al. 2007); thus our paradigm for exposure from PND 4 7 and 10 13 in mice, in terms of neurodevelopment, probably best approximates what would be the perinatal period in the human, encompassing the time frame shortly before and after birth.
FYVE-GFP, a marker of sorting endosomes which also localizes to multivesicular endosomes [72], [76], surrounded SBD-TMR in some cases, and colocalization at moderate levels encompassed a longer time frame from a presumptive sorting compartment (30 min; 30 35%) to late endosomal compartments (1.5 2 h; ∼25 30%)(fig. 6C, D).
A database encompassing the 2004 2011 time frame was selected so that data could be obtained for a large sample of patients for a sufficient length of time to capture significant differences in uncommon perinatal outcomes and determine whether descriptive trends emerged over time.
The time frame for events as reported by included studies encompassed 30 days.
