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These approaches require invasive procedures for tissue biopsies, which are not always readily accessible for sampling, could be of insufficient quality, and require time for mutation analysis.
Let n be the total number of possible mutations and define T i as the waiting time for mutation i∈{1,…, n}=[ n].
The A. baumannii 53264 strain was isolated about a month after the A. baumannii 48055 strain was isolated, which would explain the additional time for mutation.
HRM is a simple and rapid scanning method for known and unknown BRCA1 and BRCA2 germline mutations that can dramatically reduce the amount of sequencing required and reduce the turnaround time for mutation screening and testing.
The increased number of generations allows more time for mutation events and therefore leads to a more genetically heterogeneous data set – that is, one that contains many different genotypes.
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That is, longer intervals between speciation events allows more time for mutations to accumulate.
This is why cancer usually occurs in older people: There has been more time for mutations to occur and for exposure to cancer-causing agents.
Such risks are superimposed on the inherent risk of living longer: more time for mutations to accumulate.
Since it takes time for cancer cells to develop new mutations and then select those life-sustaining ones via clonal expansion, "run against time for mutations to emerge" should be a crucial principle for treatment of those currently incurable cancers.
Interestingly, this basin sharing is seen with the ND1 gene in sharp-snouted but not blunt-snouted lenok perhaps reflecting a longer period of allopatry between the two basins for blunts, allowing sufficient time for mutations to occur.
We expect shorter branches to be resolved in favor of mtDNA, given that there may be too little time for mutations to accumulate on the shortest branches for slower-evolving nuclear genes.
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