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IP injections of ghrelin (0.3 nmol – 3.0 nmol kg-1 BW and saline controls) decreased colonic transit time dose related.
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Results obtained from MTT analysis showed that SB715992 had a time and dose related effect on the growth of PC-3 cells.
This allows us to capture the dynamic changes of MoDC response to these nine different permutations of time and dose related challenging.
As a result, SB715992 had also shown a time and dose related effect on the increase of apoptosis, which was correlated with our results obtained from MTT assay.
This time and dose related interaction of influenza virus and pneumococcus in enhancing MoDCs pro-inflammatory cytokines may be the first trigger for the enhanced lung inflammation in patients with co-infection.
The effects of Fraction (R + P G on the incidence of SqM and SqN were both time and dose related, the effect on SqM incidence being already evident after 10 weeks of treatment.
These findings are consistent with mouse study showing a time and dose related synergistic lethality of influenza virus and pneumococcus [ 19], in which the greatest mortality of sequential infection occured when secondary pneumococal infection comes at 7 days, but not 0 to 3 days nor 14 to 21 days after influenza virus infection.
Since it was anticipated that dosing regimens would be individualized, it was necessary to account for variation of the dose over time, since some events may be dose related.
Analysis of the data for the minipigs confirmed that this effect of biperiden on the time taken to find the food reward was not dose related (Dose X Sessions interaction: F5,35 = 1.16, p = 0.3476).
The ethanolic rhizome extract of C. zedoaria presented a longer latency time than the control group in the hot plate test in a dose related manner.
Minor variations in heart rate over time were observed for all treatment groups, including placebo; none were considered to be dose related or clinically relevant (Table 5).
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