In addition to the time-dependent transition from green to red, MitoTimer age profile (overall color) will depend on rates of synthesis/import of new (green) protein and degradation of old (red) protein.
The origin of the differential wear between grains is considered and the implications of the experimental observations on the time-dependent transition to severe wear in aluminas are discussed.
Coupled hysteresis and thermomagnetic analyses demonstrate how Nd-Fe-B feature a time-dependent transition from square-like ferromagnetic to superparamagnetic loop via pot-bellied and wasp-waist loops, whereas SmCo and AlNiCo do not show so extensive corrosion-related variations of the intrinsic and extrinsic magnetic properties.
Next, we simulate 100 genealogies with a linear time-dependent transition rate (λ∝ time, Eq. 6).
To account for any emerging time trends in observed parameters, regression methods were used to derive time-dependent transition probabilities.
For cost-effectiveness analyses, we used the model incorporating time-dependent transition probabilities and a mixed population assumption.
We included both time-dependent transition probabilities and the mixed population assumption in a more complex model.
We then enhanced the basic model first by using time-dependent transition probabilities to evaluate the effect of latency on disease progression.
I would therefore request that the authors extend the type of display in Figure 1G, developing a time-dependent transition probability model.
The model that provided the best fit with the empirically derived constraints incorporated both time-dependent transition probabilities and a mixed population assumption.
Generalizing the model to allow for time-dependent transition probabilities is another possibility which could be done by including a lactation stage effect in the analysis of the transitions.
