The analysis is complex due to competing events, clustering, multiple timescales and time-dependent period and intervention variables.
Reactions were terminated by the addition of a 3% phosphoric acid solution (for some kinases, other solutions were used) after an incubation period (time dependent on kinase) at room temperature.
Animations can visualise time dependent data by defining a period of time which is run through a series of time steps.
This finding was also time dependent; as the follow-up period progressed, the risk decreased to 0.99.
Toxicity was concentration dependent (increasing with increased N/P molar charge ratio) and time dependent (duration of the incubation period) as previously described [ 18].
The interval between transplantation and diagnosis of cancer is time dependent, so the follow-up period will let us know if the incidence is modified with length of follow-up.
This extended reassessment interval was chosen to accommodate the fact that random measurement error is often time dependent, and in practice, the period between clinical visits is often greater than several months [ 33].
The results of the studies described here suggest that insulin treatment by implants or islet transplantation promotes beta-cell regeneration in the STZ-diabetic mouse model of beta-cell regeneration, and does so in a time dependent manner with longer treatment periods associated with greater recovery.
The association of each investigated variable with all-cause mortality was tested by univariate and multivariate analysis using time dependent Poisson regression models with study period divided into intervals of 1-year duration, which provided estimates of relative risks (RRs), their 95% CIs and p-values.
24 Compared with conventional meta-analyses that use aggregate data from publications, the availability of individual patient data allowed us to provide a more informative analysis of time dependent data derived from the whole period of follow-up with calculation of hazard ratios.
Therefore, the anticipatory time was divided into a reaction time-dependent anticipation period (AT, like in Study 1), with a value of 1800 msec minus RT, and a reaction time-independent anticipation period, i.e., parametric AT PATT), with values of 0, 500, and 1000 msec.
