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As part of a clinical trial we collected prospective data on the time course of headache and other symptoms relative to the aura.
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Primary headache was 16.6% of all painful pathological conditions treated. Figure 1 shows the time course of primary headache during the 5-week observation period: a higher prevalence is evident during the first 3 weeks.
We assessed, also, the prevalence of allodynia during attacks and recorded CPT in scheduled cranial-facial areas outside headache crisis, to determine if they were altered, and to correlate the variation of this parameter to the time course of the headache itself.
Fig. 1 Time course of sodium derangements.
Fig. 1 Time course of pain intensity.
b Time course of the face rubbing.
Figure 1 Time course of main variables.
Time course of the NPC.
In humans, the time course for the headache phase of migraine can last from 4 to 72 h.
Additionally, studies indicate that being diagnosed with migraine at baseline may influence the course of headache and the headache frequency at a later time point.
Fig. 2 Course of headache during menopause.
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