Published methods for the measurement of urinary vitamin E metabolites typically involve deconjugation, extraction, and derivatization steps, which are time consuming and risk the artifactual formation of α-TL from α-CEHC [9].
Since the whole FDA process is time consuming, high risk and expensive, the FDA approval sometimes can be a big barrier for any medical device aiming for clinical applications.
Although IDT is considered the preferred diagnostic method among dermatologists, ASIS has several advantages over IDT, such as: no patient risk (no sedation required), less traumatic (no repeated injection required), more convenient (no clipping needed, less time consuming), and lower risk of drugs interfering with test results (concurrent anti-inflammatory/antipruritic therapy) [ 45, 46].
However, completion of the family history questionnaire and analysis is time consuming and the risk prediction depends on the accuracy of the entered data as well as on the physician/specialist nurse to analyse.
Recently an efficient method to isolate BM-MSCs using novel marrow filter device is explored [ 38], which is less time consuming and avoids the risk of external contamination.
Although blood and tissue cultures remain the 'gold standard' for diagnosis, they show low sensitivity, are time consuming, and represent a risk for laboratory personnel [ 4, 5].
However, this method necessitates invasive blood sample collection and biochemical examination, which are time consuming and laborious and risk patient injury.
This is time consuming and you could risk breaking down.
Whereas viral strategies are time consuming and involve safety risks, non-viral methods proved to be inefficient for most primary cell types.
The selection and preparation of MSCs through adherence to culture plastic is time consuming, and introduces additional risks such as immunogenicity and infection through exposure to animal-derived culture products.
