Most third-party payers require time-consuming prior authorization for all TCI prescriptions.
The clinical significance of splice isoforms remains to be elucidated, mainly because their detection has until recently required time consuming cloning steps prior to sequencing.
Equine bone marrow derived autologous MSCs require time consuming in vitro propagation prior to transplantation and a decreased yield of stem cells from the bone marrow with increasing age makes the technique age-dependent which is paradoxical to the fact that many clinical cases are aged individuals [ 10].
Sample size estimation using economic end points is possible, but it is both time consuming, thus generally infeasible prior to obtaining funding, and will more likely produce a sample size that is larger than that required for the clinical effect; this increases the cost of a trial, and thus deceases the likelihood of successfully receiving funding.
The advantage of such a preliminary screen is that recombinant proteins containing guanylate cyclase activity are identified prior to time consuming full characterization studies as outlined in Figure 7.
However, at times, the set-up and calibration was found to be time consuming and re-calibration is necessary prior to capturing the image.
These methods are technically demanding, require construction of genomic libraries prior to hybridization, are time consuming and do not scale well with the number of samples.
Completion of diaries is a time consuming occupation, may alter behaviour, and require prior user training.
Nevertheless, this will be necessarily a time consuming and costly process and requires reasonable prior hypotheses to be generated.
Prior to Pepper, draftsmanship was a "time consuming" and "frustrating rather than enlightening" business.
Prior approaches in development of Short Tandem Repeats (STR) markers were time consuming and inefficient.
