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Exact(2)
Phylogenetic foot printing using programs such as ECR browser and ConSite present potentially powerful tools in identifying regulatory elements, enabling the analysis of these sequences without time consuming functional studies.
As our results suggest, the MSI-H phenotype in 3/11 tumors from MSH6 VUS carriers is more likely to be linked to the MLH1 promoter hypermethylation than MSH6 variations found in the families, and thus, if MLH1 expression is lost in the tumor, its promoter hypermethylation should be assayed before the more challenging and time consuming functional assays.
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Compared with the time and cost consuming functional MRI, ultrasound examination offers advantages because of the simple demonstration in previously mentioned areas.
FB1 is a time-consuming functional block.
Thus, clearly, searching for BMI-associated varinnts in African American populations can provide extremely useful information to guide expensive and time-consuming functional studies that may lead to either universal or population-specific prevention and treatment regimens.
It is likely that future eQTL fine-mapping studies that encompass direct genotyping of likely causal SNPs of interest in larger datasets of tumor and normal tissue will inform the role of eQTL data in the design of time-consuming functional analysis studies of candidate causal SNPs.
It is very difficult and time consuming to elicit functional dependencies from transactions manually for the reengineering, verification and maintenance of database applications.
Validating that software components meet required functional and non-functional properties is time consuming and for some properties quite challenging.
In addition, functional testing is time consuming, and requires investment and training to get started.
Identifying regulatory genomic sequences through functional assays is time consuming and problematic.
Their functional assays are time consuming, expensive, and cumbersome, thereby limiting the number and types of assays that can be performed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com