Since Cyber-Physical Systems (CPS) may exhibit different structures and emergent behaviours during different operational phases, while also being safety critical, it is useful to perform systematic safety analyses tightly relying on the functional and components topologies of such systems.
In this system, cyclin degradation tightly relies on the ubiquitin ligase Anaphase Promoting Complex/Cyclosome (APC/C) in association with its co-activator Cdc20 and assembly of APC/CCdc20 is required for efficient ubiquitin ligase activity [3], [18].
Taken together, these results underline that SPEM and attention are very tightly yoked processes that rely on substantially overlapping neural substrates [5], [43], [44].
Thus, whereas the shape and size of the core and the arrangement of the spikes may rely on tightly wrapped outer membrane layers, the decondensation of the viral DNA critically depended on cell surface binding.
Invadopodia biogenesis and integrity rely on tightly controlled levels of plasma membrane cholesterol.
Other, looser reaction complexes may rely on tightly bound waters (as may be identified by crystallography of sufficient resolution) and/or more mobile waters to provide water molecules that are hydrogen-bonded to NTPs and ligands of metals.
T cell activation and effector function is tightly controlled and relies on fairly stable cell-cell contacts especially during primary activation and communication with antigen-presenting cells (APCs).
Our suspicion is that this does not reflect true differences but that our proportion of patients that met criteria for NTM lung disease was an underestimate because we relied tightly on chest CT scans performed at our institution within 6 weeks of the isolate.
This potential drawback of performance-based conventional selection may be overcome by the use of modern breeding approaches that rely on molecular markers tightly linked to loci controlling field performance.
Furthermore, importin- and exportin-mediated transport cycles are driven by tightly coupled RanGTPase cycles, which, again, rely on the NPC barrier for retaining free RanGTP inside the nuclear compartment.
