Sentence examples for tightly regulation from inspiring English sources

The tetracycline-responsive system is an ideal system for tightly regulation gene expression mediated by rAAV [ 29], because it is the tet responsive cassette inducible unit whose activity is modified in response to Dox.

Taken together, when designing these vectors for toxic gene expression, the following properties had to be taken into account: a strong promoter capable of tightly regulation, strong terminators against read-through transcription from other plasmid-borne promoters, and different copy numbered origins of replication for gene expression with different degrees of toxicity.

This observation is consistent with the idea of regulatory gene cascades, that genes involved in regulation are themselves tightly regulated, allowing master regulators to exert overall control of gene regulation 'programs' to reprogram cells [ 28].

However, while B-raf alternative splicing is obvious in avian and mouse tissues [17], [20], B-raf splice variants are barely detectable in most established cell lines, suggesting that this mode of regulation is tightly regulated by extracellular signals and/or cell-cell interactions within different tissues, which might be lost in culture conditions.

Many complex traits are tightly regulated and incorporating regulation factors may explain a relevant portion of observed variations due to true heterogeneity (i.e. true differences in effect sizes).

In general, in WT cells, the transient nature of the IFNα response is tightly regulated by up-regulation of suppressor of cytokine signalling 1 (SOCS1) [ 40].

A number of transcription research studies have emphasized that asexual stage development of Plasmodium falciparum is tightly regulated because of gene regulation by transcription factors, acetylation/methylation of genes as well as by protein Post Translational Modifications (PTMs) [ 2].

Apoptosis is a tightly regulated cellular process and faulty regulation of apoptosis is a hallmark of human cancers.

The allosteric regulation of Hsp70 s is tightly regulated by various cochaperones.

Activation and deactivation of Raf isoforms are tightly regulated, although the mechanisms involved in this regulation are not fully known.

Neurogenesis is a tightly regulated process that is coordinated with cell cycle regulation and cell fate determination.