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The two lipid binding assays mostly differ in detection of Ca2+-independent interactions, especially in the case of PtdInsP2s and PtdInsP3 where binding to these lipids is prominent when they are packed less tightly in the context of liposomes.
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The observation of seven ectopic interactions also underlines that the interaction potential of the disordered region is tightly controlled in the context of the full-length protein.
By modifying the RCAS viral vectors to place Kras under the control of tetracycline, Kras overexpression can be tightly controlled in the context of Akt activation.
Although the pathophysiology of Ewing sarcoma is thought to be tightly related to transcriptional alterations in the context of the t(11 22) EWS/FLI1 translocation, therapies related to this altered fusion protein have not yet been incorporated into practice.
In the context of tightly controlled therapeutic trials, the answer is "now".
Indeed, chromatin modifications are tightly associated with the vernalization pathway in the context of the epigenetic repression of floral inhibitors.
41 Secondly, the positive results produced in this study arose in the context of a tightly delivered research intervention.
This needs to be considered in the context of a tightly regulated trial setting with good levels of compliance.
This reveals the molecular basis for the uptake of HpHb and trypanolytic factor-1 and identifies adaptations in the trypanosome receptor that allow efficient ligand uptake in the context of the tightly packed VSG coat.
An armed conflict should be placed in the context of history and it should be tightly linked to an over-arching foreign policy.
Current knowledge points to close links between Panx1 and cytoskeletal dynamics, and the cell behaviours in which Panx1 appears to be involved in the context of neurogenesis (proliferation, migration, neurite outgrowth) are all tightly linked to the cytoskeleton.
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