Do you think it was easy to organize all those restless criminal spirits into such a well-oiled, tightly functioning machine?
Phosphorylation of Ser487 was dynamically regulated after DNA damage suggesting a tightly regulated function for this modification.
Cofilin-1 is known to be a key regulator of actin dynamics at the leading edge of motile cells; it has a tightly regulated function of creating new actin barbed ends for polymerization and also depolymerizes old actin filaments [ 41].
Thus, the groups of genes identified are for the most part tightly interrelated in function, with functions directly related to the etiology of PAH.
In accordance with these tightly linked functions of Nab3 and Nrd1, we found that overexpression of NRD1 also suppresses some esa1 mutant phenotypes.
In terrestrial vertebrates, IT and CD have tightly linked functions in water conservation, whereby urea secretion by the IT establishes high extracellular solute concentrations that aid in water reabsorption from the CD (Pannabecker, 2012).
The amplifications along both the vertebrate and subsequent teleost lineages of the type I transmembrane family (MT-MMPs), suggest that the genes are highly retained following duplication, presumably by subfunctionalization into tissue-specific forms, and may have a less tightly constrained functions than other members within the MMP gene sub-family.
The manufacturer of your fryer model should provide instructions for performing an annual inspection to make sure all the parts are fitted together tightly and functioning properly.
For selection to converge on similar sequences, sequence space must be tightly coupled to function space, so that independent selection pathways for the same function would be likely to result in similar sequences.
Spine volume is tightly coupled with function: larger spines have a wider postsynaptic density, more functional AMPARs, and likely produce larger excitatory postsynaptic potential (Harris et al., 1992; Matsuzaki et al., 2001; Kasai et al., 2010).
